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IC50s for the pan TGF-β antibody, Fresolumimab in ECM accumulation assay for total and individual ECM markers
| Geomean IC50, nM | Range, nM | Number | |
|---|---|---|---|
| Total ECM proteins | 236.6 | 126.8–490 | 4 |
| Fibronectin | 158.0 | 124–202 | 4 |
| Collagens I and III | 187.6 | 131.3–215.1 | 4 |
| Collagen IV | 255.5 | 119.3–1,614 | 4 |
| Collagen V | 118.2 | 86.1–160.6 | 4 |
ECM, extracellular matrix; TGF-β, transforming growth factor-β.
