Table 5.

IC50s for the pan TGF-β antibody, the integrin αV antibody and the combination of the pan TGF-β and integrin αV antibodies

	Geomean IC50, nM	Range, nM	Number
Anti-TGFβ
Total ECM proteins	140.5	109.7–181.4	3
Fibronectin	165.6	122.6–249.2	4
Collagens I and III	102.4	39–200	3
Collagen IV	81.3	30.9–177.9	3
Collagen V	111.6	84.3–195.8	3
Anti-integrinαV
Total ECM proteins	0.550	0.418–0.67	4
Fibronectin	0.905	0.629–1.185	4
Collagens I and III	0.725	0.513–1.032	4
Collagen IV	0.630	0.375–1.465	4
Collagen V	0.368	0.317–0.451	4
Anti-TGFβ+ anti-integrinαV
Total ECM proteins	1.096	0.769–1.678	3
Fibronectin	1.435	0.965–2.157	3
Collagens I and III	1.076	0.693–1.472	3
Collagen IV	1.348	1.008–1.748	3
Collagen V	0.497	0.439–0.596	3

ECM, extracellular matrix; TGF-β, transforming growth factor β.