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Vitamin D analogs with A-ring modifications. The table summarizes the biological properties of the compounds: reference, 1,25(OH)2D3; (=) similar value; (+) >10× higher; (−) >10× lower; (--), >100× lower; VDR aff, VDR affinity; 24OH trans, CYP24A1 transactivation activity; HL60 diff, HL-60 cell differentiation induction.
