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. 2019 Mar 27;62(15):6854–6875. doi: 10.1021/acs.jmedchem.9b00208

Table 1. Vitamin D Compounds on the Marketa.

• Vitamin D3 (1, calciferol) is used worldwide in the prevention of vitamin D deficiency and associated diseases, such as rickets [Vigantol (Bayer), Delsterol (DuPont), Duphafral-D3 (multiple pharma companies), Lutavit D3 (BASF), Vi-D3, Videkhol, Vigosan (multiple pharma companies)].
• Vitamin D2 (2, ergocalciferol) is also used in the prevention of vitamin D deficiency and associated diseases, such as rickets (marketed with different names by multiple pharma companies).
• Calcidiol (3, 25(OH)D3) is used in the treatment of chronic hypocalcemia, renal osteodystrophy [Calderol (Upjohn), Hidroferol (Faes Farma)], rickets [Dedrogyl (Roussel), Hidroferol (Faes Farma)].
• Calcitriol [4, 1,25(OH)2D3] is prescribed for renal osteodystrophy [Rocatrol (Roche), Calcijex (Abbott)], osteoporosis [Rocatrol (Roche)] and psoriasis [Silkis (Galderma)].
• Calcipotriol [5, 22-ene-26,27-dehydro-1,25(OH)2D3] is used for psoriasis [Davionex (Leo Pharmaceuticals), Dovonex (Warner Chilcott)].
• Doxercalciferol [6, 1α(OH)D2, Hectorol (Bone Care International)] is prescribed for secondary hyperparathyrodism.
• Alfacalcidol (7, 1α(OH)D3) is used for renal osteodystrophy [Alfarol (Chugai Pharmaceutical), One-Alpha (Leo Pharmaceuticals)], secondary hyper-parathyrodism [Alfarol (Chugai Pharmaceutical)], osteoporosis [Alfarol (Chugai Pharmaceutical), Alpha D3 (Teva Pharmaceuticals)] and rickets [Alfarol (Chugai Pharmaceutical)].
• Tacalcitol (8, 1α,24(OH)2D3) is prescribed for psoriasis [Bonalfa (Teijin), Curatoderm (Merck KGaA)].
• Paricalcitol [9, 19-nor-1,25(OH)2D2, Zemplar, (Abbott Laboratories)] is used for secondary hyperparathyrodism.
• Oxacalcitriol (10, 22-oxa-1,25(OH)2D3) is used for secondary hyperparathyrodism and psoriasis [Oxarol (Chugai Pharmaceuticals)] in Japan.
• Falecalcitriol [11, 1,25(OH)2-26,27-F6-D3] is prescribed for secondary hyper-parathyrodism in Japan [Hornel (Taisho Pharmaceuticals and Sumitomo Pharmaceuticals), Fulstan (Kissei Pharmaceuticals)].
• Eldecalcitol [12, 2α-(3-hydroxypropoxy)-1,25(OH)2D3] is prescribed for osteoporosis only in Japan [Edirol (Chugai Pharmaceutical)].
a

Only a few vitamin D compounds have reached the market.88,89 Their applications, commercial name, and company are listed. The structures of the compounds are shown in Figure 1.