Table 1.

Summary of KIT localization and signaling in AML, MCL, and GIST

Cell line, KIT mutation	KIT localization	Downstream activation	Reference
Kasumi-1 (AML), N822K	EL	Golgi	This study
HMC-1.1 (MCL), V560G	EL	Golgi
HMC-1.2/RCM (MCL), D816V/D814Y	EL	ER, EL	[24, 25]
GIST cell lines (ex11/17 etc…), NIH3T3 (transfected KITD816V etc…)	Golgi	Golgi	[26–29, 30]

AML acute myeloid leukemia, MCL mast cell leukemia, GIST gastrointestinal stromal tumor, Ex exon, EL endo-lysosomes, ER endoplasmic reticulum