Table 1.
Telemetry parameters of female mice
| Ace2 fl/fl | Ace2 Adipo | |||
|---|---|---|---|---|
| LF | HF | LF | HF | |
| 24 h | ||||
| MAP (mmHg) | 105.3 ± 1.1 | 112.4 ± 2.1* | 106.1 ± 0.7 | 117.7 ± 2.1, # |
| Heart rate (bpm) | 584 ± 8 | 617 ± 9* | 563 ± 4# | 622 ± 7* |
| Activity (counts/min) | 12.8 ± 1.4 | 6.5 ± 0.6* | 9.9 ± 1.5 | 6.4 ± 0.8* |
| PP (mmHg) | 32.2 ± 1.2 | 30.8 ± 1.4 | 30.7 ± 1.5 | 32.0 ± 1.5 |
| Light | ||||
| SBP (mmHg) | 115.3 ± 1.1 | 122.3 ± 1.9* | 114.9 ± 1.3 | 127.8 ± 2.5* |
| DBP (mmHg) | 84.5 ± 0.8 | 92.7 ± 2.4* | 85.2 ± 1.3 | 97.1 ± 1.0* |
| MAP (mmHg) | 100.7 ± 0.7 | 100.8 ± 2.0* | 100.8 ± 1.2 | 113.3 ± 2.1*, # |
| Heart rate (bpm) | 576.6 ± 8.2 | 606.8 ± 9.3* | 549.0 ± 4.5 | 610.8 ± 9.5* |
| Activity (counts/min) | 7.1 ± 1.0 | 4.9 ± 0.4* | 5.8 ± 0.7 | 4.3 ± 0.7 |
| PP (mmHg) | 30.8 ± 1.2 | 29.6 ± 1.3 | 29.7 ± 1.3 | 30.6 ± 1.3 |
| Dark | ||||
| SBP (mmHg) | 128.3 ± 0.4 | 134.3 ± 1.9 | 129.0 ± 1.7 | 139.7 ± 2.4* |
| DBP (mmHg) | 94.0 ± 1.6 | 101.4 ± 2.8* | 96.7 ± 0.6 | 105.3 ± 1.7* |
| MAP (mmHg) | 111.8 ± 1.6 | 118.5 ± 2.2* | 113.5 ± 0.9 | 123.6 ± 2.0* |
| Heart rate (bpm) | 596.4 ± 8.1 | 634.0 ± 8.4* | 578.9 ± 6.8 | 635.0 ± 7.0* |
| Activity (counts/min) | 20.0 ± 1.8 | 8.9 ± 0.8* | 15.1 ± 2.5 | 9.4 ± 1.2* |
| PP (mmHg) | 34.4 ± 1.3 | 32.9 ± 1.5 | 32.2 ± 1.7 | 33.8 ± 1.4 |
PP pulse pressure, SBP systolic blood pressure, DBP diastolic blood pressure, MAP mean arterial pressure
Data are mean ± SEM (n = 4–5 mice/diet/genotype)
*p < 0.05 compared to LF within genotype following pairwise statistical analysis
#p < 0.05 compared to Ace2fl/fl within the diet group following pairwise statistical analysis