Table 2.
Telemetry parameters of male mice
| Ace2 fl/y | Ace2 Adipo | |||
|---|---|---|---|---|
| LF | HF | LF | HF | |
| 24 h | ||||
| MAP (mmHg) | 112.5 ± 0.8 | 117.7 ± 0.7* | 114.1 ± 0.9 | 115.3 ± 1.2 |
| Heart rate (bpm) | 556.7 ± 6.7 | 582.2 ± 7.5* | 559.7 ± 6.5 | 581.1 ± 14.2* |
| Activity (counts/min) | 5.9 ± 0.7 | 5.0 ± 0.5 | 5.6 ± 0.8 | 5.5 ± 0.7 |
| PP (mmHg) | 31.3 ± 2.1 | 38.2 ± 1.0 | 33.8 ± 2.0 | 33.18 ± 2.8 |
| Light | ||||
| SBP (mmHg) | 120.9 ± 1.3 | 130.0 ± 1.6* | 123.88 ± 1.6 | 128.8 ± 2.5 |
| DBP (mmHg) | 91.6 ± 0.6 | 93.3 ± 1.1 | 91.9 ± 1.2 | 94.6 ± 1.6 |
| MAP (mmHg) | 106.3 ± 0.4 | 112.2 ± 1.2* | 108.1 ± 0.8 | 110.9 ± 1.5 |
| Heart rate (bpm) | 524.3 ± 5.2 | 555.3 ± 10.1* | 534.6 ± 11.1 | 561.4 ± 13.0 |
| Activity (counts/min) | 3.0 ± 0.3 | 3.3 ± 0.5 | 3.0 ± 0.4 | 3.5 ± 0.2 |
| PP (mmHg) | 29.2 ± 1.9 | 35.6 ± 0.8 | 31.9 ± 1.9 | 32.3 ± 2.5 |
| Dark | ||||
| SBP (mmHg) | 139.0 ± 1.3 | 142.1 ± 2.3 | 140.5 ± 2.5 | 134.5 ± 3.7 |
| DBP (mmHg) | 105.3 ± 2.1 | 104.3 ± 1.2 | 104.1 ± 1.0 | 102.5 ± 1.6 |
| MAP (mmHg) | 122.3 ± 1.3 | 125.4 ± 1.7 | 122.4 ± 1.4 | 120.4 ± 2.2 |
| Heart rate (bpm) | 598.6 ± 10.6 | 621.3 ± 7.7 | 595.3 ± 3.7 | 614.9 ± 15.0 |
| Activity (counts/min) | 10.8 ± 1.1 | 7.3 ± 0.7 | 9.2 ± 1.4 | 7.4 ± 1.7 |
| PP (mmHg) | 33.7 ± 2.5 | 40.9 ± 1.4 | 36.4 ± 2.2 | 35.1 ± 3.0 |
PP pulse pressure, SBP systolic blood pressure, DBP diastolic blood pressure, MAP mean arterial pressure
Data are mean ± SEM (n = 4–5 mice/diet/genotype)
*p < 0.05 compared to LF within genotype following pairwise statistical analysis
#p < 0.05 compared to Ace2fl/y within the diet group following pairwise statistical analysis