Table 2.
Summary Table of Medications for Adolescent Substance Use Disorders
| SUD indication | Medication | Number of studies and participants | Safety/tolerability | SUD outcomes |
|---|---|---|---|---|
| Alcohol use disorder | Naltrexone | 3 (N = 155) | Positive | Mixed/mostly positive |
| Cannabis use disorder | N-acetylcysteine | 1 (N = 116) | Positive | Positive |
| Tobacco use disorder | Nicotine replacement therapy | 9 (N = 1118) | Positive (negative for nasal sprayer) | Mixed for patch, mostly negative for nasal sprayer |
| Bupropion SR | 3 (N = 657) | Positive | Positive at 300 mg | |
| Varenicline | 3 (N = 258) + 1 pending publication (N = 307) | Positive | Preliminary/encouraging | |
| Opioid use disorder | Buprenorphine (Buprenorphine/Naloxone) | 3 (N = 241) | Positive | Positive |
| Methamphetamine use disorder | Bupropion SR | 1 (N = 19) | Positive | Negative |
SUD, substance use disorder.