Table 4.
Reported clinical parameters
| First author | Heart rate | Initial blood lactate levels | Peak blood lactate levels | Creatinine levels | Arterial pH | Mean arterial pressure | SOFA score | APACHE II score | APACHE III score | Mechanical ventilation | Vasopressor infusion |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Contenti et al.a [21] | 100 ± 25 vs 109 ± 25 bpm; p = 0.02 | 3.9 ± 2.3 mmol/L vs 5.6 ± 3.6 mmol/L; p = 0.0006 | – | – | – | 72 mmHg ± 22 vs 70 mmHg ± 21; p = 0.48 | 5.0 ± 2.8 vs 5.3 ± 2.8; p = 0.44 | 21.0 ± 6.0 vs 21.7 ± 6.9; p = 0.41 | – | 15% vs 19%; p = 0.58 | 31% vs 32%; p = 0.94 |
| Sharma et al.a [25] | – | – | 3.2 vs 3.6 mmol/L; p = 0.54 | – | – | – | – | – | 94 vs 84; p = 0.14 | – |
Cumulative dose 11.4 vs 12.6 mg; p = 0.43 Duration of infusion 1563 vs 1730 min; p = 0.37 |
| Charles et al.a [23] | 81 (IQR 82–111) vs. 107 (IQR 89–122) bpm; p < 0.01 | 1.75 (IQR 0.9–3.4) vs. 1.8(IQR 0.8–4) mmol/L; p = 0.97 | – | 165.5 (IQR 108–245) vs 135.5 (IQR 82–108); p < 0.00 | 7.35 (IQR 7.25–7.42) vs 7.34 (IQR 7.23–7.42); p = 0.354 | – | 9 (IQR 6–12) vs 9 (IQR 6–13); p = 0.242 | – | – |
81.7% vs 84.9%; p = 0.112 Days on ventilation 4 (IQR 2–9) vs 5.5 (IQR 2–11); p = 0.055 |
23.2 mg (IQR 5.1–57.0) vs 22.4 mg (IQR 5.2–60.5); p = 0.95 |
| Fuchs et al.b [26] | 111 (IQR 97.0–132.8) vs 118 (IQR 97.0–135.5); p = 0.2 | 2.3 (IQR 1.5–3.8) vs 3.5 (IQR 2.0–6.5); p < 0.01 | – | – | – | – | – | 20.0 (IQR 15.0–24.5) vs 21.0 (IQR 16.2–26.0); p = 0.25 | – | – | Norepinephrine 91% vs 92.2%; p = 0.83 |
aPremorbid beta blocker exposure vs no premorbid beta blocker exposure
bContinued beta blocker usage during sepsis vs discontinued beta blocker usage during sepsis