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. 2019 Sep 5;10:46. doi: 10.1186/s13293-019-0259-1

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© The Author(s). 2019

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Protein-protein interaction networks. a PPIs were constructed from differentially expressed genes from male and female ES cells. The networks includes sex-biased modules highlighted by red (female-enriched) and blue (male-enriched) nodes. b PPI network compared to genes in the blue/violet module from the WGCNA analysis. The most important module (based on topological analysis) is encircled. The common genes are green, unique genes are orange; squares represent male-biased and circles female-biased genes