Fig. 1.

Low-dose radiation improves abscopal responses based on RECIST criteria. a, the percentage of lesions showing a clinical response based on RECIST criteria (CR/PR) was 53% (20 of 38) in low-dose lesions compared to 18% (8 of 45) no-dose lesions, ***P < 0.001. b, the median change for the sum of the longest diameter for low-dose lesions was − 38.5% (range − 100 to 68%) compared to 8% (range − 75 to 132%) in no-dose lesions, ****P < 0.0001. c, the percentage of lesions responding according to radiation dose. *P < 0.05. d, of the lesions from 22 patients with both no-dose (n = 45) and low-dose (n = 33) lesions, 12 lesions (36%) had low-dose-only responses at 6 months, and two (4%) had no-dose-only responses. e, Waterfall plot of no-dose tumor responses in patients having both lesion types. f, Waterfall plot of low-dose tumor responses in patients having both lesion types. g, Waterfall plot of low-dose tumors receiving 5–10 Gy in patients having both lesion types. h, Waterfall plot of low-dose tumors with NSCLC histology