Table 2. Pharmacokinetic Parameters of Intravenously Administered ⁶⁸Ga-labeled Anti-miR-15b RNA Oligonucleotides and Control Tracers in Healthy Adult Rats^a.

tracer	AUC0→∞ (min × g/mL)	ClT (mL/min × g)	kel (mL/min × g)	t1/2 (min)	Cmax (mL/g)	Tmax (s)
[68Ga]Ga-NOTA-anti-miR-15b	120.0 ± 3.6	0.0083 ± 0.0003	0.0231 ± 0.0030	30.4 ± 3.9	23.6 ± 1.6	5.0 ± 0.0
[68Ga]Ga-NOTA(mod)-anti-miR-15b	125.6 ± 14.9	0.0080 ± 0.0010	0.0209 ± 0.0031	33.7 ± 5.5	18.3 ± 6.8	25.0 ± 26.5
[68Ga]Ga-DOTA-anti-miR-15b	229.7 ± 128.1	0.0057 ± 0.0032	0.0155 ± 0.0056	48.7 ± 15.2	16.8 ± 3.1	17.5 ± 12.6
[68Ga]Ga-NOTA-anti-miR-15b(scr)	101.8 ± 5.6	0.0098 ± 0.0005	0.0257 ± 0.0021	27.1 ± 2.2	15.4 ± 1.7	10.0 ± 5.8
[68Ga]Ga-NOTA-anti-miR-15b(2SBS)	68.6 ± 6.6	0.0147 ± 0.0015	0.0220 ± 0.0016	31.7 ± 2.2	8.6 ± 0.9	79.5 ± 17.5
[68Ga]Ga-NOTA-anti-miR-34	92.3 ± 21.1	0.0112 ± 0.0024	0.0201 ± 0.0024	34.9 ± 4.5	14.4 ± 5.8	30.5 ± 6.0
[68Ga]Ga-NOTA-T6	100.2 ± 13.7	0.0101 ± 0.0013	0.0329 ± 0.0066	21.7 ± 4.4	17.3 ± 3.9	7.5 ± 5.0
[68Ga]Ga-NOTA	100.0 ± 15.7	0.0102 ± 0.0017	0.0323 ± 0.0083	22.4 ± 5.3	18.6 ± 2.4	12.5 ± 5.0

^aAUC_0→∞ = area under the curve; Cl_T = total clearance; k_el = elimination rate constant; t_1/2 = plasma half-life; C_max = maximum concentration; T_max = time of maximum concentration.