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. Author manuscript; available in PMC: 2020 Feb 19.
Published in final edited form as: Anal Chem. 2019 Feb 6;91(4):2805–2812. doi: 10.1021/acs.analchem.8b04699

Figure 8.

Figure 8.

LCMS data for brentuximab vedotin, analogous to Figure 5. (a) Full-range raw mass spectra show even stronger signals for light chain+drug than observed for the AbbVie model ADC. (b) Chromatogram for UV detection (top) approximately tracks that of EIC for signal of light chain+drug, again indicating light chain+drug dissociated after separation. Again, the blue arrows show two peaks that changed intensities, and the inset depicts the structures for the D4 isomers that are consistent with these changes.