Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Aug 29;10:587. doi: 10.3389/fendo.2019.00587

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Costa and Reagan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

In vivo rodent models show irradiation alters the bone marrow microenvironment by increasing osteoclast numbers per bone surface (Oc.S/BS) and decreasing osteoblast numbers per bone surface (Ob.S/BS) resulting in decreased trabecular bone volume with a rapid influx of bone marrow adipocytes. (A) Non-irradiated control, demonstrates normal bone turnover processes. (B) Irradiated (2-20Gy), demonstrates the uncoupling of the bone formation/resorption ratio through increased CTX/TRAP5 (osteoclast activity) and decreased RUNX2 (osteoblast activity) expression. In vivo irradiation exposure also has increased CEBPα and PPARγ (adipogenesis markers), and IL-6, TNF-α, and VEGF (inflammatory and senescent markers).