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. 2019 Jul 15;30(15):1846–1863. doi: 10.1091/mbc.E19-01-0073

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© 2019 Pipaliya et al. “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology.

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FIGURE 2: — Coulson plot depicting distribution of ARF GEF subfamilies across eukaryotic taxa. Three ARF GEF subfamilies are present in at least four eukaryotic supergroups, indicating their presence in the LECA. Opisthokonta-specific families include EFA6, IQSEC7, and FBX8. EFA6 is found only in holozoa and fungi, with numerous paralogues present in both lineages. FBX8 is specific to the metazoa but is missing from some early-diverging animals. Large taxonomic groups are color coded. Sectors with solid colors indicate orthology based on a combination of RBH, domain structure, and phylogenetic analyses while light colors indicate putative orthology. The presence of multiple paralogues are indicated by numbers within each sector. The key for the species name abbreviations is boxed. The total number of Sec7 domain-containing proteins identified in each organism is indicated in brackets. Eukaryotic classification is based on Adl et al. (2019).