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. 2019 Jul 1;30(14):1691–1704. doi: 10.1091/mbc.E18-10-0666

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© 2019 Heath and Wignall. “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology.

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FIGURE 7: — Model for Kif4’s roles in oocyte meiosis. Under normal conditions, Kif4 is chromosome-associated and then relocalizes to form ring-shaped structures in the midzone that contain PRC1 and MgcRacGAP1, and that stabilize the anaphase spindle (top). In the absence of Kif4 (bottom), PRC1 no longer concentrates into midzone structures, leading to elongated anaphase spindles with a disorganized central spindle. Kif4 (red), microtubules (green), DNA (blue), midzone complex (orange), and PRC1 (yellow).