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. 2019 Jul 22;30(16):2076–2086. doi: 10.1091/mbc.E19-02-0079

FIGURE 1:

FIGURE 1:

Structure of LINC complexes at the nuclear envelope. (A) Schematic representation of LINC complex: inner nuclear membrane (INM) protein SUN, and outer nuclear membrane (ONM) protein KASH. (i) Structure of the human SUN2–KASH2 hexamer and (ii) structure of the coiled-coil (CC1) region of mouse SUN2. (B) Model of SUN–KASH interactions at the ONM. SUN1 or SUN2 in humans binds to Nesprin1, Nesprin2. In C. elegans, ANC-1 binds to UNC-84. KASH5 (human), and UNC-83 (C. elegans) are shorter in the length of their KASH domains and also bind to SUN1/2 and UUNC-84, respectively. (C) Sequences of transmembrane and KASH domains of longer KASH domains (Nesrpin1–4 in humans and ANC-1 in C. elegans), as well as shorter KASH domains (KASH5 in humans and UNC-83, KDP-1, and ZYG-12 in C. elegans). The transmembrane domains are highlighted; a conserved C-23 and EEDY motif are highlighted on the sequences of KASH domains of longer lengths, namely, Nesprin1–3 and ANC-1.