Table 2. Association of Log-Transformed High-Sensitivity Cardiac Troponin T Concentrations With Incident Heart Failure .
| hs-cTnT Concentration | Incident HF (114 Events) | Incident HFrEF or HFmrEF (50 Events) | Incident HFpEF (53 Events) | |||
|---|---|---|---|---|---|---|
| HR (95% CI) | % Reduction of Coefficient (95% CI)a | HR (95% CI) | % Reduction of Coefficient (95% CI)a | HR (95% CI) | % Reduction of Coefficient (95% CI)a | |
| hs-cTnT (log) | 2.58 (1.87 to 3.57) | 1 [Reference] | 2.65 (1.61 to 4.35) | 1 [Reference] | 2.23 (1.39 to 3.59) | 1 [Reference] |
| hs-cTnT (log) + diastolic function | 1.99 (1.41 to 2.81) | −27 (−13 to −47) | 2.29 (1.35 to 3.88) | −17 (−0.6 to 49) | 1.64 (1.01 to 2.68) | −41 (−14 to −85) |
| hs-cTnT (log) + LV mass index (m2.7) | 1.89 (1.33 to 2.68) | −30 (−13 to −46) | 1.69 (0.97 to 2.93) | −47 (−20 to −112) | 1.79 (1.09 to 2.94) | −23 (−9 to −56) |
| hs-cTnT (log) + diastolic function + LV mass index (m2.7) | 1.66 (1.16 to 2.38) | −46 (−29 to −78) | 1.69 (0.96 to 2.97) | −47 (−20 to −112) | 1.46 (0.88 to 2.43) | −55 (−26 to −123) |
Abbreviations: HF, heart failure; HFmrEF, heart failure with midrange ejection fraction; HFpEF, heart failure with preserved ejection fraction; HFrEF, heart failure with reduced ejection fraction; HR, hazard ratio; hs-cTnT, high-sensitivity cardiac troponin T; LV, left ventricular.
a
Reduction of coefficient is a measure of proportion of the hs-cTnT and outcomes association, accounted for by diastolic function and/or LV mass index. Analyses were restricted to participants with available tissue Doppler e’, E/e’ ratio, left atrium volume index, and LV mass index (n = 3936 [95.7% of the total study population]).