TABLE 2.
Percent positive agreement between datasetsa
| Full Dataset | Percent Positive Agreement, % | ||||
|---|---|---|---|---|---|
| SDR | No SDR | ||||
| Cardiovascular Subset | SDR | Acute myocardial infarction | 1 | 0 | 100.0 |
| Atrioventricular block complete | 2 | 0 | 66.7 | ||
| Cardiogenic shock | 2 | 1 | 66.7 | ||
| Myocardial infarction | 5 | 1 | 71.4 | ||
| Arteriosclerosis coronary artery | 0 | 1 | 0.0 | ||
| Cardiac arrest | 1 | 1 | 50.0 | ||
| Cardiac failure | 1 | 2 | 33.3 | ||
| Cardiac failure congestive | 2 | 0 | 33.3 | ||
| Sudden death | 0 | 3 | 0.0 | ||
| Sudden cardiac death | 1 | 1 | 50.0 | ||
| Cerebrovascular accident | 0 | 1 | 0.0 | ||
| Cerebral infarction | 1 | 0 | 50.0 | ||
| Hemorrhagic stroke | 1 | 0 | 100.0 | ||
| Ischemic stroke | 1 | 1 | 33.3 | ||
| No SDR | Acute myocardial infarction | 0 | 20 | ||
| Atrioventricular block complete | 1 | 18 | |||
| Cardiogenic shock | 0 | 18 | |||
| Myocardial infarction | 1 | 14 | |||
| Arteriosclerosis coronary artery | 1 | 19 | |||
| Cardiac arrest | 0 | 19 | |||
| Cardiac failure | 0 | 18 | |||
| Cardiac failure congestive | 4 | 15 | |||
| Sudden death | 0 | 18 | |||
| Sudden cardiac death | 0 | 19 | |||
| Cerebrovascular accident | 3 | 17 | |||
| Cerebral infarction | 1 | 19 | |||
| Hemorrhagic stroke | 0 | 20 | |||
| Ischemic stroke | 1 | 18 | |||
Abbreviation: SDR, signal of disproportional reporting.
a
There were 21 total drug event combinations involving DPP-4i, sulfonylureas, and biguanides with major adverse cardiac events.