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. Author manuscript; available in PMC: 2020 Apr 11.
Published in final edited form as: J Med Chem. 2019 Mar 22;62(7):3503–3512. doi: 10.1021/acs.jmedchem.8b01972

Table 2.

Mouse Pharmacokinetic Data

Compound Route Animals Dose, mg/kg t1/2, h CLz, mL/min/kg Vz, L/kg F, %
12 i.v. 4 1 1.7 52 7.3 -
34 i.v. 4 2 6.6 5.9 3.2 -
34 p.o. 4 5 - - - 13
54b i.v. 4 2 4.4 3.3 1.3 -
54b p.o. 3 5 - - - 32

CLz = apparent rate of clearance; Vz = apparent volume of distribution.