Table 1:

Phenotypic alterations observed in limb regenerates in response to Doxercalciferol treatment.

Site of amputation	Dosage (mg/kg)	Total number of limbs amputated	Total number of limbs evaluatedβ	Regenerates exhibiting*¥
				Carpal fusions	Carpal duplications	Cartilage nodules**	Autopods with a reduced number of digits	Normal limbs
Proximal	0 (vehicle treated)	14	14	1 (7.14%)	3 (21.43%)	3 (21.43%)	0	8 (57.14%)
	1	10	10	2 (20%)	1 (10%)	4 (40%)	0	4 (40%)
	10	10	8	6 (75%)	0	2 (25%)	0	2 (25%)
Distal	0 (vehicle treated)	9	7	5 (71.43%)	0	1 (14.29%)	1 (11.11%)	1 (11.11%)
	1	10	10	7 (70%)	0	5 (50%)	3 (30%)	0
	10	10	10	10 (100%)	0	8 (80%)	2 (20%)	0

^*# of regenerated limbs exhibiting a specific phenotype. The % of total regenerates is provided in parentheses

^**At the site of amputation

^¥Some limbs exhibited multiple abnormalities

^βA small number of animal deaths and the failure of limbs to regenerate reduced the number of limbs that were ultimately evaluated between experimental groups