Figure 2.

IDO1-deficiency and/or 1-d-MT treatment do not affect the development of splenomegaly and autoantibody production in B6.Nba2 mice. IDO1-deficient and –sufficient B6.Nba2 mice were bred (A) and treated with PBS or 1-d-MT in the drinking water from 8 to 24 weeks of age. At 24 weeks of age, mice were harvested and spleen weights were recorded (B). Serum was obtained monthly and evaluated for total IgM (C), total IgG (D), anti-dsDNA IgG (E), anti-chromatin IgG (F), and anti-histone IgG (G). Shown are data from 24 week old mice. Each symbol represents one mouse. *p < 0.05, Student's unpaired t-test with Welch's correction.