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. 2019 Aug 29;10:1996. doi: 10.3389/fmicb.2019.01996

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Copyright © 2019 Ayoola, Shack, Nakamya, Thornton, Swiatlo and Nanduri.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of the metabolite profiles of S. pneumoniae TIGR4 and ΔcadA. Mass spectrometry-based untargeted metabolomics analysis (n = 5) was performed with the wild type and polyamine synthesis deficient strain ΔcadA. Peak intensity values of identified metabolites were analyzed by Metaboanalyst 4.0 to identify significant changes in expression. (A) Clustering of samples within the sPLS-DA principal component of the wild type strain TIGR4 (green) and deletion mutant strain ΔcadA (pink) indicate significant metabolic differences between the two strains. (B) sPLS-DA loading plot of TIGR4 and ΔcadA with top ranked metabolites with significant differences in intracellular concentrations between the strains is shown.