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. 2019 Aug 29;10:1996. doi: 10.3389/fmicb.2019.01996

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Copyright © 2019 Ayoola, Shack, Nakamya, Thornton, Swiatlo and Nanduri.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Measurement of secreted pyruvic acid from Spn TIGR4 and ΔcadA. Secreted pyruvate in a putative lysine decarboxylase deficient ΔcadA strain and Spn TIGR4 was measured using Pyruvic Acid Assay Kit (Megazyme, Bray, Ireland) according to the manufacturer’s protocol. Results show that secreted pyruvate levels in ΔcadA were ∼60% lower compared to the wild type strain. This data suggest that the glycolytic pathway is impaired in the polyamine synthesis deficient pneumococci. ^∗indicate significance at P ≤ 0.05.