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. 2019 Sep 30;38(3):260–266. doi: 10.23876/j.krcp.19.050

Figure 1. Model showing the involvement of the exocyst in ciliogenesis.

Figure 1

Genes are transcribed into messenger RNA (mRNA) in the nucleus, and mRNA is translated into proteins in the endoplasmic reticulum. Proteins destined for the primary cilium are packaged in vesicles in the trans-Golgi network and trafficked to the primary cilium by the exocyst complex. The small GTPase Cdc42 localizes the exocyst to the primary cilium. Exoc5 is a central exocyst member because it connects Exoc6 (bound to the vesicle via Rab8) to the rest of the exocyst complex. Adapted from reference [36].