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. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: Curr Protoc Cell Biol. 2019 Sep;84(1):e89. doi: 10.1002/cpcb.89

Figure 4. Principles of Representative ChIP-seq Variations.

Figure 4

A) N-ChIP-seq uses MNase digestion of chromatin with no crosslinking or sonication step. B) ChIP-exo requires exonuclease digestion of crosslinked and sonicated chromatin. C) X-ChIP-seq starts with crosslinking but is followed by MNase digestion with no sonication. Libraries are also enriched for short fragments.