Figure 2.

(A) Mean (±SE) body weight in dams over gestation and the postnatal period. No significant alterations were detected at any time point. (B,D) Mean (±SE) body weight of pups from PN5 to PN21. The bar graph insert represents weights at PN5 and PN10 for clarity. Slight reductions were seen and appeared greater in male than in female offspring. (C) Pup eye opening was slightly delayed in pups from CON-PTU and PTU-PTU conditions. No effect was seen in pups with exposure confined primarily to the gestational period (PTU-CON). Significant main effects in ANOVA were followed by mean contrast tests, Dunnett’s t-test, *p<.05. (E) Mean (±SE) thyroid gland weight did not differ in dams euthanized on PN21, 1 week after termination of exposure. (F) Mean (±SE) thyroid gland weights were significantly higher at PN10 in all animals receiving PTU treatment. By PN14 only animals concurrently receiving PTU had larger thyroid glands, which had returned to control levels by PN18 on termination of exposure 4 days earlier. Significant main effects in ANOVA were followed by mean contrast tests, Dunnett’s t-test, *p<.05.