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. Author manuscript; available in PMC: 2019 Sep 5.
Published in final edited form as: Toxicol Sci. 2018 May 1;163(1):101–115. doi: 10.1093/toxsci/kfy016

Figure 6.

Figure 6.

Effect of Sex. (A) Mean (±SE) heterotopia volume in adult female and male brains. Heterotopia were present in the brains of male and female PTUPTU offspring and did not differ in size as a function of sex. (B) As males and females were derived from different dams as a function of the cross-fostering protocol, Experiment 2 was conducted and confirmed the lack of effect of sex on heterotopia formation in male and female littermates sacrificed on PN15. (C) The overall incidence of heterotopia (criterion>0.003mm3) was calculated across all animals examined in the cross-fostering study (32–34 animals/ treatment condition). This assessment confirms the confinement of heterotopia to animals exposed to PTU during the gestational period. *Signifies significantly different from CON-CON.