Figure 13.

Time course of the evolution of the normalized GS, ES and net magnetization during an off-resonance R_1ρ experiment, simulated using the B-M equations. Time course for the positions of the tips of the GS, ES and net magnetization vectors (each with their base at the origin), denoted as solid blue, red and black lines respectively, with green dots in each case denoting the positions of the vector tips at the start of the relaxation period, and violet dots denoting their positions at the end of the relaxation period, respectively. Directions for the GS,ES and AVG effective fields are denoted using blue, red and green dashed lines, respectively. Also shown as insets are the variations of the normalized projections of the net magnetization along ω_eff,OBS (M) as a function of time (black dots), along an exponential fit of the same (red line). Simulations were performed using k_ex = 20000 s⁻¹ for panel A, k_ex = 20 s⁻¹ for panels B and C. The other parameters used for all simulations were p_ES = 0.1, $\Delta \overline{\omega }{(}^{13}\text{C)}=3\text{\hspace{0.17em}ppm}$, γ(¹H)B₀/2π = 700 MHz, R_1,GS = R_1,ES = 2.5 s⁻¹, R_2,GS = R_2,ES = 22.5 s⁻¹ and T_max = 0.25 s. The initial alignment of the magnetization for the B-M and vector simulations was achieved as described in Section 6.1.