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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Prog Nucl Magn Reson Spectrosc. 2019 May 11;112-113:55–102. doi: 10.1016/j.pnmrs.2019.05.002

Figure 39.

Figure 39.

RNA ESs feature localized changes in secondary structure. Shown are the secondary structures of ES determined for A) bacterial A-site, B) p5abc and C) HIV-SL1 using selective 1D R1ρ RD measurements. The part of the ES undergoing structural changes on transforming from the GS is indicated in red. Thick lines correspond to Watson-Crick BPs and G-U mismatches, whereas thin lines denote other non-canonical mispairing. The populations of the states and the rate constants for GS-ES exchange, as obtained using R1ρ RD measurements[9, 16] are also shown.