Figure 2.
Mu-opioid system activation during sustained masseter muscle pain. Brain regions where significant decreases in the nondisplacable binding potential (BPND), meaning lower mu-opioid receptor availability, from placebo to sustained pain are illustrated on the left. The scatter plot with the respective values in the thalamus is presented on the right. PFCTX BA 8, prefrontal cortex, Brodmann areas 8/9; A THA, anterior thalamus; INS, anterior insular cortex; HYPO, hypothalamus; AMY, amygdala.72 From Zubieta JK, Smith YR, Bueller JA, Xu Y, Kilbourn MR, Jewett DM, Meyer CR, Koeppe RA, Stohler CS. Regional mu opioid receptor regulation of sensory and affective dimensions of pain. Science 2001; 293:311–5. Reprinted with permission from AAAS.