Table 1. Cohort characteristics at the time of ARDS diagnosis, stratified by the presence/absence of Day 3 AKI and stratified by 60-day mortality.
| Variable | All (n = 161) |
No Day 3 AKI (n = 126, 78%) |
Day 3 AKI (n = 35, 22%) |
p value | Survived (n = 136, 84%) |
Deceased (n = 25, 16%) |
p value |
|---|---|---|---|---|---|---|---|
| Age (years) | 4.4 (1.1, 11.7) | 5.9 (1.5, 11.8) | 2.2 (0.4, 11.3) | 0.21 | 3.4 (1.1, 11.3) | 10.4 (2.9, 13.9) | 0.11 |
| Sex (% male) | 92 (57%) | 71 (56%) | 21 (60%) | 0.70 | 73 (54%) | 19 (76%) | 0.038 |
| Race: | 0.21 | 1.00 | |||||
| Caucasian/white | 112 (70%) | 91 (72%) | 21 (60%) | 95 (70%) | 17 (68%) | ||
| African-American/black | 14 (9%) | 9 (7%) | 5 (14%) | 12 (9%) | 2 (8%) | ||
| Asian/Pacific Islander | 13 (8%) | 8 (6%) | 5 (14%) | 11 (8%) | 2 (8%) | ||
| Other | 22 (14%) | 18 (14%) | 4 (11%) | 18 (13%) | 4 (16%) | ||
| ARDS etiology: | 0.40 | 0.49 | |||||
| Pneumonia | 96 (60%) | 78 (62%) | 18 (51%) | 80 (58%) | 16 (64%) | ||
| Sepsis | 30 (19%) | 21 (17%) | 9 (26%) | 25 (18%) | 5 (20%) | ||
| Aspiration | 9 (6%) | 6 (5%) | 3 (9%) | 7 (5%) | 2 (8%) | ||
| Trauma | 6 (4%) | 5 (4%) | 1 (3%) | 5 (4%) | 1 (4%) | ||
| Transfusion | 1 (1%) | 1 (1%) | 0 (0%) | 1 (1%) | 0 (0%) | ||
| Other | 18 (11%) | 15 (12%) | 3 (9%) | 18 (13%) | 0 (0%) | ||
| Missing | 1 (1%) | 0 (0%) | 1 (3%) | 0 (0%) | 1 (4%) | ||
| Primary insult (% direct ARDS) | 107 (66%) | 86 (68%) | 21 (62%) | 0.48 | 89 (65%) | 18 (75%) | 0.36 |
| Type of respiratory support: | 0.67 | 0.65 | |||||
| Conventional mechanical ventilation | 144 (89%) | 112 (89%) | 32 (91%) | 121 (89%) | 23 (92%) | ||
| High frequency oscillatory ventilation | 7 (4%) | 6 (5%) | 1 (3%) | 6 (4%) | 1 (4%) | ||
| CPAP or BiPAP | 10 (6%) | 8 (6%) | 2 (6%) | 9 (7%) | 1 (4%) | ||
| Kidney function (% AKI) | 35 (22%) | n/a | n/a | n/a | 28 (21%) | 7 (28%) | 0.41 |
| Day 1 PaO2/FiO2 ratio | 153 (91, 228) | 162 (93, 223) | 129 (89, 243) | 0.50 | 163 (92, 246) | 135 (84, 172) | 0.06 |
| Day 1 oxygenation index | 9 (5, 18) | 8 (5, 16) | 12 (6, 19) | 0.25 | 8 (5, 16) | 10 (8, 24) | 0.07 |
| Day 1 PRISM score | 11 (6, 18) | 10 (5, 17) | 16 (10, 22) | 0.001 | 11 (5, 17) | 15 (9, 19) | 0.04 |
| Day 1 serum IL-6 (pg/ml) (n = 135) | 75 (26, 227) | 70 (18, 185) | 138 (41, 1540) | 0.004 | 72 (24, 222) | 107 (28, 689) | 0.21 |
| Day 1 plasma total FGF23 (RU/ml) | 223 (114, 774) | 166 (89, 466) | 944 (357, 6556) | <0.001 | 202 (100, 669) | 529 (172, 1490) | 0.017 |
| Day 1 plasma intact FGF23 (pg/ml) | 23 (11, 60) | 21 (11, 41) | 28 (13, 105) | 0.09 | 21 (10, 43) | 38 (13, 128) | 0.037 |
| Data presented as numbers (percentages) or medians (interquartile range). | |||||||