Table 2. Scope of the Reductive Liebeskind–Srogl Alkylation^a,b.

^aThioether (1 equiv, 0.2 mmol), alkyl bromide (2.0 equiv), NiBr₂·diglyme (10 mol %), dppf (10 mol %), K₂HPO₄ (2.0 equiv), Zn (2.5 equiv), 4 Å MS, DMA (0.6 mL) at 100 °C, 6 h.

^bIsolated yields.

^cAlkyl bromide (3.0 equiv).

^d50 °C, 24 h.

^e12 h.

^fTraces of alkylation at Ph–S cleavage observed by GC-MS.