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. Author manuscript; available in PMC: 2019 Sep 5.
Published in final edited form as: Gene. 2015 Sep 28;575(2 Pt 3):584–599. doi: 10.1016/j.gene.2015.09.061

Table 1 -.

Functional findings of commonly studied NOS3 polymorphisms.

Rs number Common name Location Functional findings Reference
rs2070744 g.-786T>C Promoter C allele results in lower NOS3 transcriptional activity compared with T allele. (Nakayama et al., 1999; Wang et al., 2002)
- 4b/4a VNTR Intron 4 4a allele leads to decreased levels of NOS3 mRNA in relation to 4b allele. (Zhang et al., 2008a; Zhang et al., 2008b)
rs1799983 Glu298Asp Exon 7 Variant allele results in lower NOS3 activity than ancestral allele. (Joshi et al., 2007)
rs3918226 g.-665C>T Promoter T allele is associated with reduced NOS3 transcriptional activity compared with C allele. (Salvi et al., 2013)