Table 2.
Compound | Structure | Target | Ref. |
---|---|---|---|
Nutlin-3 | MDM2-p53 Interaction | [193] | |
Terphenyl helix mimetic (core structure) | MDM2-p53 Interaction | [199] | |
Isoindolinone (core structure) | MDM2-p53 nteraction | [201] | |
Spiro-oxindole (MI-63) | MDM2-p53 Interaction | [202] | |
1,4-benzodiazepin −2,5-dione | MDM2-p53 Interaction | [203] | |
HLI98C | E3 Ubiquitin Ligase | [205] | |
Sempervirine | E3 Ubiquitin Ligase | [206] | |
Chalcone (generic core structure) | MDM2-p53 Interaction | [207] | |
Cyclic peptide derived from chlorofusin | MDM2-p53 Interaction | [213] | |
Apigenin | MDM2 Expression | [214] | |
Genistein | MDM2 expression | [10] | |
Curcumin | MDM2 expression | [11] | |
25-OCH3-PPD (a ginsenoside) | MDM2 expression | [15] | |
25-OH-PPD (a ginsenoside) | MDM2 expression | [16] |