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. Author manuscript; available in PMC: 2019 Sep 5.
Published in final edited form as: Anticancer Agents Med Chem. 2009 Oct;9(8):882–903. doi: 10.2174/187152009789124628

Table 2.

Structures of the Small-Molecule Inhibitors of MDM2 and the MDM2-p53 Interaction

Compound Structure Target Ref.
Nutlin-3 graphic file with name nihms-1041466-t0002.jpg MDM2-p53 Interaction [193]
Terphenyl helix mimetic (core structure) graphic file with name nihms-1041466-t0003.jpg MDM2-p53 Interaction [199]
Isoindolinone (core structure) graphic file with name nihms-1041466-t0004.jpg MDM2-p53 nteraction [201]
Spiro-oxindole (MI-63) graphic file with name nihms-1041466-t0005.jpg MDM2-p53 Interaction [202]
1,4-benzodiazepin −2,5-dione graphic file with name nihms-1041466-t0006.jpg MDM2-p53 Interaction [203]
HLI98C graphic file with name nihms-1041466-t0007.jpg E3 Ubiquitin Ligase [205]
Sempervirine graphic file with name nihms-1041466-t0008.jpg E3 Ubiquitin Ligase [206]
Chalcone (generic core structure) graphic file with name nihms-1041466-t0009.jpg MDM2-p53 Interaction [207]
Cyclic peptide derived from chlorofusin graphic file with name nihms-1041466-t0010.jpg MDM2-p53 Interaction [213]
Apigenin graphic file with name nihms-1041466-t0011.jpg MDM2 Expression [214]
Genistein graphic file with name nihms-1041466-t0012.jpg MDM2 expression [10]
Curcumin graphic file with name nihms-1041466-t0013.jpg MDM2 expression [11]
25-OCH3-PPD (a ginsenoside) graphic file with name nihms-1041466-t0014.jpg MDM2 expression [15]
25-OH-PPD (a ginsenoside) graphic file with name nihms-1041466-t0015.jpg MDM2 expression [16]