Table 1:

Reported genetic polymorphisms associated with Chemotherapy-Induced Peripheral Neuropathy.

Agent	Mechanism	Gene (-SNP)	Functional Pathway	Reference
Platinum	Interfere with tumor cell proliferation by forming DNA-platinum adducts that accumulate in the DRG and in peripheral neurons.10,13	ERCC1	DNA repair	13,27
		ERCC 2	DNA repair	28–30
		XRCC1	Cell cycle progression, RNA transcription, DNA repair, and possibly repair after platinum induced damage to DRG	31,32
		CCNH	Oxidative damage protection	33
		GPX7	Transporter enzyme	33
		ABCC4	Glutathione	33
Taxanes Paclitaxel	Stabilization of microtubules and inhibition of depolymerization, forming abnormal microtubule bundles in the cytoplasm and producing mitotic spindle disruption and apoptosis.34	CYP2C8	Metabolizes paclitaxel	37–41
		ABCB1	Cellular and systemic drug efflux transporter	41–44
		TUBB2A	Molecular target for paclitaxel	44,45
		FGD4	Myelin production	51
		EPHA4,5,6	Nervous system development / repair	41,45, 53–55
		ARHGEF10	Neurodevelopment	58,59
Docetaxel		ABCB1	Cellular and systemic drug efflux transporter	65–67
		GSTP1	Drug conjugation and detoxification	66,68 69
		VAC14	Neurodevelopment	71–74
Vinca Alkaloids	Promote disassembly of microtubules by binding to tubulin during S phase and preventing microtubule polymerization, disrupting mitotic spindle formation in M phase and rendering cell unable to divide.74	CEP72	Microtubule formation	75–79
		CYP3A5	Vincristine metabolism	80−89
Bortezomib	Indirectly polymerize tubulin, causing microtubule stabilization, axonal transport inhibition and G2-M phase cell cycle arrest.93	CTLA4 rs4553808	Immune function	94
		PSMB1 rs1474642	Drug binding	94
		PKNOX1–21q22.3	Severe bortezomib-IPN	96
		CDH13, DCC, TENM3: 4q34.3-rs6552496, 5q14.1- rs12521798, 16q23.3- rs8060632, 18q21.2- rs17748074	Unknown: Intergenic	95
Thalidomide	Inhibit production of IL-6 (growth factor), blocks the cell growth-stimulating CD147/MCT1 protein complex from binding to Cereblon, activate apoptotic pathways through caspase 8-mediated cell death, and activates T cells to produce IL-2 augmenting NK-dependent cytotoxicity.97,101	ABCA1	Neuroinflammation, neurodegeneration	98,100
		ICAM1	Myelinogenesis, nerve regeneration	98,100
		PPARD	Promote mitochondrial biogenesis	98,100
		SERPINB2	Proteostasis, neuro-cytoprotection	98, 100
		SLC12A6	K & Cl cotransporter	98, 100
		GSTT1	Drug conjugation and detoxification	99