Table 3.
Adjusteda percent change (95% confidence interval) in urinary oxidative stress biomarker in association with an interquartile range difference in urinary phenol concentrationb.
| 8-OHdG |
8-isoprostane |
|||
|---|---|---|---|---|
| % Change (95% CI) | P | % Change (95% CI) | P | |
| 2,4-DCP | 9.16 (5.95, 12.5) | < 0.01 | 8.47 (3.46, 13.7) | < 0.01 |
| 2,5-DCP | 15.2 (11.0, 19.6) | < 0.01 | 16.7 (9.66, 24.2) | < 0.01 |
| BP3 | 10.0 (5.46, 14.8) | < 0.01 | 9.00 (1.39, 17.2) | 0.02 |
| Butyl PB | 3.32 (−1.21, 8.04) | 0.17 | 9.92 (1.80, 18.7) | 0.02 |
| Ethyl PB | 4.28 (−0.19, 8.95) | 0.07 | 12.8 (5.01, 21.1) | < 0.01 |
| Methyl PB | 9.30 (5.40, 13.3) | < 0.01 | 9.50 (3.32, 16.1) | < 0.01 |
| Propyl PB | 7.32 (3.55, 11.2) | < 0.01 | 7.32 (1.27, 13.7) | 0.01 |
| Triclosan | 6.12 (2.08, 10.3) | < 0.01 | 7.02 (0.14, 14.4) | 0.05 |
| BPSb | 6.18 (−0.27, 13.1) | 0.06 | 18.5 (7.68, 30.5) | < 0.01 |
| Triclocarbanb | 3.05 (−6.76, 13.9) | 0.56 | 3.87 (−11.7, 22.2) | 0.65 |
Abbreviations: DCP, dichlorophenols; BP3, benzophenone-3; BPS, bisphenol-S; PB, paraben; 8-OHdG, 8-hydroxydeoxyguanosine. Results from weighted linear mixed effects models including a random intercept for ID. N = 464 participants, 1555 samples.
a
Models adjusted for urinary specific gravity, gestational age at sample collection, maternal age, Race/Ethnicity, education level, pre-pregnancy body mass index, and smoking during pregnancy.
b
Bisphenol-S and triclocarban modeled as above vs. below the limit of detection.