Table I.
Body weights, baseline and endpoint systolic and diastolic blood pressure, serum cholesterol concentrations, plasma Ang-(1-7) concentrations, and complete blood counts in MasR+/+ and MasR−/− male mice. Systolic blood pressures of Apoe−/− mice were quantified by radiotelemetry. Systolic blood pressures of Ldlr−/− mice were quantified by tail-cuff. ND indicates not determined.
MasR+/+ Ldlr−/− | MasR−/− Ldlr−/− | MasR+/+ Apoe−/− | MasR−/− Apoe−/− | |
---|---|---|---|---|
Body weight (g) | 34 ± 0.8 | 31 ± 1.3 | 28 ± 0.7 | 31 ± 0.6 |
Baseline systolic blood pressure (mmHg) | 112 ± 4 | 110 ± 4 | 129 ± 8 | 124 ± 7 |
Endpoint systolic blood pressure (mmHg) | 141 ± 6 | 143 ± 2 | 158 ± 13 | 162 ± 8 |
Baseline diastolic blood pressure (mmHg) | 90 ± 2 | 84 ± 6 | 99 ± 3 | 95 ± 4 |
Endpoint diastolic blood pressure (mmHg) | 112 ± 7 | 110 ± 1 | 133 ± 8 | 133 ± 5 |
Serum cholesterol (mg/dl) | 1624 ± 130 | 2204 ± 418 | 326 ± 21 | 349 ± 25 |
Plasma Ang-(1-7) (ng/mL) | 0.1 ± 0.01 | 0.1 ± 0.02 | ND | ND |
WBCs (K/μL) | 4.0 ± 0.5 | 3.7 ± 0.2 | ND | ND |
Platelets (K/μL) | 606 ± 35 | 604 ± 40 | ND | ND |
Hematocrit (%) | 38 ± 0.7 | 35 ± 1.5 | ND | ND |