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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Curr Opin Biotechnol. 2019 Mar 5;60:146–152. doi: 10.1016/j.copbio.2019.01.013

Figure1. Impact of BBB disruption on Particle Access to CNS.

Figure1.

a) Under normal conditions healthy, intact BBB separates the CNS from blood components thereby preventing nanocarriers from accessing CNS. b) Under conditions in which a disease induces pathologic BBB disruption, therapeutic nanocarriers can directly Interact with disease site. c) Focus Ultrasound (FUS) can exert mechanical forces that temporarily disrupt the BBB allowing therapeutic nanocarriers to directly Interact with the CNS.