Table 2.
| Studies Utilizing Induced BBB Disruption | Neuropathology | Particle Type | Therapeutic Payload |
|---|---|---|---|
| Timbie KF et al. [35] | F98 Glioma | Pegylated Polyaspartic acid | Cisplatin |
| Coluccia D et al. [32] | U251 GBM | Peptide targeting Au NC | Cisplatin |
| Rodríguez-Frutos B et al. [39] | Subcortical Stroke | Lipid Microbubbles | BDNF |
| Wang H-B et al. [40] | MCAO Stroke | Lipid Microbubbles | pVEGF |
| Long L et al. [49] | 6-OHDA, PD | Pegylated Liposomes | pNrf2 |
| Mead BP et al. [34] | 6-OHDA, PD | Pegylated-PEI | pGDNF |
NC=nanocarrier, PEI=poly(ethyleneimine), p=plasmid, BDNF= Brain-derived neurotrophic factor, VEGF=vascular endothelial growth factor, Nrf2=nuclear factor erythroid 2-related factor 2, GDNF=glial cell-derived neurotrophic factor.