Table 2.

Studies Utilizing Induced BBB Disruption	Neuropathology	Particle Type	Therapeutic Payload
Timbie KF et al. [35]	F98 Glioma	Pegylated Polyaspartic acid	Cisplatin
Coluccia D et al. [32]	U251 GBM	Peptide targeting Au NC	Cisplatin
Rodríguez-Frutos B et al. [39]	Subcortical Stroke	Lipid Microbubbles	BDNF
Wang H-B et al. [40]	MCAO Stroke	Lipid Microbubbles	pVEGF
Long L et al. [49]	6-OHDA, PD	Pegylated Liposomes	pNrf2
Mead BP et al. [34]	6-OHDA, PD	Pegylated-PEI	pGDNF

NC=nanocarrier, PEI=poly(ethyleneimine), p=plasmid, BDNF= Brain-derived neurotrophic factor, VEGF=vascular endothelial growth factor, Nrf2=nuclear factor erythroid 2-related factor 2, GDNF=glial cell-derived neurotrophic factor.