Fig. 1.

Upregulated D1r transcription in DISC1-deficient mice. a Relative transcript abundance of D1r in the striatum (n = 12), hippocampus (n = 6), and prefrontal cortex (n = 6) of adult (12-week-old) Disc1 (Δ2–3/Δ2–3) mice (right) and those of wild-type (WT) B6 mice (left) assayed by real-time qRT-PCR. b Relative transcript abundance of D1r in the striatum (n = 6), hippocampus (n = 10), and prefrontal cortex (n = 6) of Disc1-LI mice (right), compared with those of WT B6 mice (left). c Increased protein level of D1R in the striatum of adult Disc1-LI mice (n = 3). d Reduced transcript level of D1r in differentiated CAD cells upon overexpression of Flag-DISC1 (n = 8). e Decreased acetylation level of histone H3 in differentiated CAD cells upon Flag-DISC1 overexpression (n = 3). Anti-AcH3 (K9 and K14) antibody was used for IP. Columns represent mean ± SEM. *P < 0.05; ***P < 0.001; two-tailed t test