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. 2019 Mar 28;56(10):6807–6819. doi: 10.1007/s12035-019-1555-9

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© The Author(s) 2019

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — Changes in Smad1/BMP4 signalling pathway. a Q-PCR confirmed good correlation between microarray and Q-PCR data. b Immunohistochemistry for pSmad1 (green) in sections of regenerating (SN, pSN + DC) and non-regenerating (IC, DC) NF200⁺ DRGN (red) and of satellite cells (DAPI⁺ nuclei—blue). High levels of pSmad1 immunoreactivity were detected in occasional nuclei of regenerating SN and many nuclei of pSN + DC DRGN. c Immunohistochemistry for BMP4 (green) in sections of regenerating (SN, pSN + DC) and non-regenerating (IC, DC) NF200⁺ DRGN (red) and of satellite cells (DAPI⁺ nuclei–blue). BMP4 immunoreactivity was detected in most regenerating SN and pSN + DC DRGN. d Immunohistochemistry for Noggin in sections of regenerating (SN, pSN + DC) and non-regenerating (IC, DC) DRGN. Noggin immunoreactivity was highest in sham and DC whilst lower levels of immunoreactivity were detected in regenerating SN and pSN + DC DRGN. Scale bars in b–d = 50 μm