Fig. 2.

Possible treatment strategies according to biomarker status in mCRC. ^aWhere maximum tumour shrinkage is the goal; further confirmatory data are needed. Colours indicate possible treatment strategies for tumours with amplified HER2 (pink), mutant BRAF (green), MSI-H (light orange), WT RAS; (yellow) and mutant RAS (orange). Grey shading indicates WT/normal expression/MSS with no treatment recommendations. AMP amplified, B binimetinib, Bev bevacizumab, BRAF B-rapidly accelerated fibrosarcoma, Cmab cetuximab, CT chemotherapy, D dabrafenib, E encorafenib, EGFR epidermal growth factor receptor, FOLFIRI leucovorin, fluorouracil and irinotecan, FOLFOX leucovorin, fluorouracil and oxaliplatin, FOLFOXIRI leucovorin, fluorouracil, irinotecan and oxaliplatin, HER2 human epidermal growth factor 2, Ir irinotecan, L lapatinib, mCRC metastatic colorectal cancer, MSI-H microsatellite instability high, MSS microsatellite stable, MUT mutant, NORM normal, Pmab panitumumab, Pz pertuzumab, RAS rat sarcoma, T trametinib, Tz trastuzumab, V vemurafenib, WT wild type