Fig. 6.

Identification of synthetic retinoids that act on the GluR1 5′ UTR region. SH-SY5Y^RARα were transfected with pTK1 containing the rat GluR1 5′ UTR region and with pRL-TK. After 24 h, they were treated with 10 μM of retinoids. After a further 24 h, cells were lysed and luciferase activities were measured as described. The graph shows firefly luciferase activity normalised with respect to Renilla luciferase activity, with activity in cells treated with DMSO only set at 1. Shown are mean values of three biological replicates. Error bars indicate SEM (*p ≤ 0.05; **p ≤ 0.01, one-way ANOVA with Newman-Keuls multiple comparison test)