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. 2019 Sep 5;10:4003. doi: 10.1038/s41467-019-11944-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — IL-36 cytokine expression levels in the serum of obese patients. a–d IL-36α, β, γ and IL-36Ra levels in the serum of lean individuals (n = 37), obese non-diabetic patients (HbA1c < 48) (n = 51) and obese with diabetes (HbA1c ≥ 48) (n = 16), as measured by ELISA. e–h Correlation analysis of IL-36γ levels with HbA1c and FBG in the serum of diabetic obese patients (e, f) and non-diabetic obese patients (g, h). Spearman correlation coefficient (r) and the corresponding p value shown. For (a–d) data are shown as means ± SEM, statistical analysis by two-tailed Mann–Whitney test, **p < 0.01, ****p < 0.0001. DM: diabetes mellitus. Source data are provided as a Source Data file