Table 2.
Same- and cross-trait associations of polygenic risk scores with circulating 25-hydroxyvitamin D, omega-3 fatty acids, and major depressive disorder in >2000 participants from NESDA
| 25-OH-D | n3-PUFA | MDD | |||||||
|---|---|---|---|---|---|---|---|---|---|
| N = 2013 | Mean = 64.8 (28.2) nmol/L | N = 2010 | Mean = 0.39 (0.13) nmol/L | 1700 cases + 347 controls | |||||
| PRS | β | 95% CIs | p Value | β | 95% CIs | p Value | OR | 95% CIs | p Value |
| 25-OH-D | 5.29 | 4.18–6.39 | 1.4E − 20 | −0.001 | −0.01 to 0.004 | 0.74 | 0.94 | 0.84–1.06 | 0.34 |
| n3-PUFA | −0.49 | −1.61 to 0.63 | 0.39 | 0.01 | 0.007–0.02 | 9.3E − 06 | 1.01 | 0.90–1.14 | 0.83 |
| MDD | −0.57 | −1.70 to 0.55 | 0.32 | 0.001 | −0.03 to 0.01 | 0.58 | 1.26 | 1.12–1.41 | 1.4E − 04 |
Results from linear (outcome: 25-OH-D, n3-PUFA) and binary logistic (outcome: MDD) regression analyses adjusted for sex and ten ancestry-informative genetic principal components
Unit of measure 25-OH-D, n3-PUFA: nmol/L (multiply by 0.4 to obtain ng/mL)
Bold values indicates statistically significant p < 0.05