Table 2.

Variables Significantly Associated with Oral cGVHD in Univariate Analysis and Multivariable Regression Model of Factors Highly Predictive of Oral cGVHD

Univariate Analysis		Non-oral cGVHD (N = 147)	Oral cGVHD (N = 44)	p-value
Patient, transplant, and cGVHD characteristics
Quiescent or de novo cGVHD onset vs. progressive onset		79/138 (57.2%)	33/44 (75%)	0.0495
NIH average score		1.02 (0.03)	1.21 (0.07)	0.033
Laboratory parameters
Albumin		3.7 (0.04)	3.43 (0.07)	0.0008
Total complement		132.05 (3.35)	148.25 (5.99)	0.012
Patient-reported measures
Bother by avoidance of certain foods due to mouth pain (yes vs. no)		50/117 (42.7%)	30/36 (83.3%)	< 0.0001
Bother by ulcers in mouth (yes vs. no)		37/117 (31.6%)	24/36 (66.7%)	< 0.0001
Mouth pain		1.1 (0.21)	3.83 (0.56)	< 0.0001
Mouth sensitivity		2.12 (0.28)	4.17 (0.53)	< 0.0001
Multivariable logistical regression analysis
Variable	Estimate	Standard Error	Chi-square	p-value
Albumin	−1.15	0.25	20.47	<0.0001
Total complement	0.016	0.0056	8.02	0.0046
Mouth pain	0.35	0.080	19.58	<0.0001

For each group (oral and non-oral cGVHD), continuous variables are shown as means (standard error of the mean). Categorical variables are shown as proportions (percentages) for each group.

cGVHD indicates chronic graft vs. host disease, and NIH indicates National Institutes of Health.

The final model was determined by backward selection. In the context of an exploratory analysis, only p-values < 0.01 could be considered potentially statistically significant with respect to the individual univariate results.

cGVHD indicated chronic graft vs. host disease.