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. 2019 Jun 20;98(9):1020–1026. doi: 10.1177/0022034519855348

Figure 3.

Figure 3.

Loss of LiaS mediates resistance to Streptococcus parasanguinis and peroxynitrite-mediated nitrosative stress. (A) Plate inhibition assay of S. parasanguinis (Sp) and wild-type Streptococcus mutans, the liaS mutant, and complemented strains. (B) Biofilm formation of wild-type S. mutans, the liaS mutant, and complemented strains. RT-qPCR of (C) liaS and (D) liaR in response to hydrogen peroxide, nitrite, nitrate, and peroxynitrite. (E) RT-qPCR of S. mutans response regulators liaR, comE, and vicR in response to nitrate. Values are presented as mean ± SD. **P < 0.01. ***P < 0.001. comp, complemented strains; RT-qPCR, quantitative reverse transcription polymerase chain reaction; THB, Todd-Hewitt broth; WT, wild type.