Table 2.
Predictors of Successful Kasai Portoenterostomy (Bilirubin < 2 mg/dl at 6 Months)—Univariate and Multivariate Analysis.
| Factors | Successful KPE (n = 29) | Unsuccessful KPE (n = 50) | Effect size (95% CI) | P value | Logistic Regression Analysis |
|---|---|---|---|---|---|
| Age of Presentation (days) | 69.7 ± 17.9 | 85.5 ± 32 | −16 (-27 to -5) | 0.006 | Not included in LRA |
| Age at KPE (days) | 78.9 ± 15.9 | 96.4 ± 33.7 | −17 (-29 to -6) | 0.003 | Adj OR 0.97 (95% CI: 0.95–0.99); P = 0.038 |
| Total bilirubin (mg/dl) | 9.9 ± 3.2 | 10.7 ± 3.6 | −0.9 (−2.5 to 0.7) | 0.287 | |
| Aspartate aminotransferase (IU/ml) | 285 ± 345 | 332 ± 212 | −47 (−185 to 95) | 0.507 | |
| Alanine aminotransferase (IU/ml) | 187 ± 152 | 238 ± 188 | −51 (−142 to 39) | 0.260 | |
| Serum albumin (G/dl) | 3.5 ± 0.4 | 3.3 ± 0.5 | 0.2 (−0.14 to 0.36) | 0.365 | |
| Transient elastography (kPa) | 34.6 ± 28.3 | 41.8 ± 26.2 | −7.2 (−21 to 6.5) | 0.297 | |
| Presence of BASM | 1 (3.4%) | 7 (14%) | 0.2 (0.03–1.8)a | 0.246 | |
| Presence of DPM | 5 (17.2%) | 7 (14%) | 1.2 (0.35–4.3)a | 0.756 | |
| Duct size (μ) | 166.4 ± 126.5 | 146 ± 136 | 20.4 (−71 to 113) | 0.657 | |
| Advanced fibrosis | 16 (55.2%) | 39 (78%) | 0.36 (0.13–0.96)a | 0.046 | NS |
| Use of steroidsafterKPE | 16 (55.2%) | 10 (20%) | 5.3 (1.9–14.8)a | 0.001 | Adj OR 5.1(95%CI: 1.7–15.6) P = 0.004 |
| Cholangitis | 15 (51.7%) | 41 (82%) | 0.24 (0.08–0.66)a | 0.009 | Adj OR 4.2 (95%CI: 1.3–13.7) P = 0.017 |
Adj OR, adjusted odds ratio; BASM, biliary atresia splenic malformation; CI, confidence interval; DPM, ductal plate malformation; kPa, kilo-Pascals; KPE, Kasai portoenterostomy; NS, not significant.
a
Effect size described in odds ratio.